What is Pharmactive Affron®

Bioactive Compounds: Lepticrosalides®

Affron® is a premium quality saffron extract that is standardized to contain a minimum of ≥3.5% Lepticrosalides®, a complex of bioactive compounds that are responsible for the numerous beneficial and organoleptic properties of this amazing product.

These compounds have been extensively studied and have been shown to have a positive impact on mood, particularly in individuals who experience stress, anxiety, or depression symptoms.

Photo of Saffron Flower


1 million people worldwide benefit from Affron® to maintain a positive mood and mental balance every day.

– Pharmactive Biotech Products –

Differentiated Values

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Affron® Improves Mood

In a randomised, double-blind, placebo-controlled study (N=128) Affron® intake of 28mg/day for 4 weeks, significantly improved mood disorders, such as tension, anger, depression, fatigue and confusion.

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POMS “Profile of Mood States”
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Mean change score of total mood disturbance after 4 weeks of treatment

Affron® Evidence in Adolescents

The results of a meticulously conducted randomized, double-blind, and placebo-controlled research study involving a total of 68 participants have now unequivocally demonstrated the potential efficacy of Affron®, a natural extract, in the management and alleviation of anxiety and depressive symptoms among adolescents aged 12 to 16 years who have been experiencing mild-to-moderate symptoms.

The study, which was carried out over a period of eight weeks, produced overwhelmingly positive results from the perspective of the adolescent participants, paving the way for further investigation into the potential mechanisms underlying the beneficial effects of Affron® and its potential role in the treatment of this vulnerable population.

The findings of this research study provide a glimmer of hope for clinicians and families struggling to manage the often debilitating symptoms of anxiety and depression in adolescents and underscore the importance of continued research into the development of novel and effective treatments for mental health conditions.

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Change in RCADS (Revised Children’s Anxiety and Depression Scale). Youth raw scores over 8-weeks.

Safranal Improves Sleep Quality

Safranal, one of the main bioactive compounds of Affron®, showed an improvement of the quality of sleep through the increase of NREM sleep duration (Non-Rapid Eye Movement), the decrease of NREM sleep latency, and the enhancement of delta power activity of NREM sleep.

After single intake of Affron®, Crocin isomers are rapidly transformed into Crocetin, whose maximum serum levels are reached within 60-90 minutes. This suggests a faster action than other antioxidant molecules (such as Zeaxanthin, Lutein or Beta-Carotene).

Main Mechanism of Action

Affron® acts mainly at two levels:

  • Reuptake inhibition of Dopamine, Norepinephrine and Serotonin, increasing the concentrations of these neurotransmitters in the synaptic cleft of neuron’s, thereby improving mood balance.
  • Antioxidant effect against the excessive oxidative stress produced during anxiety or stress processes in the central nervous system.

1st Saffron Extract Safe and Effective to Use in Combination with Antidepressants

New randomized, double-blind, placebo-controlled study (N=160 adults) demonstrated that Affron® is well tolerated administered jointly with antidepressant drugs and is effective in helping to counter unremitted depression.

After 8-weeks of Affron® intake it has bee shown that:

  • Affron® improves mood in adults currently taking a pharmaceutical antidepressant.
  • Affron® reduces depression symptoms
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  • Affron® is well-tolerated and can be safely used in combination with antidepressants. Participant reported high satisfaction ratios (71*73%)
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  • Affron® reduces side effects associated with antidepressant intake
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